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Monoclonal Antibiotics




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Problems with Monoclonal Antibodies

Today only few monoclonal antibodies are being used in human therapy because the antibodies that are being used are from mice. This poses a problem because the human immune system sees these antibodies as being foreign to the body. When the body recognizes the antibody to be foreign it immediately releases an immune response against it, which in this case produces HAMA, human anti-mouse antibodies. The HAMA immediately destroys the mouse monoclonal antibodies, which also form immune complexes that cause damage to the kidneys. Scientists must figure out a way to create monoclonal antibodies from humans instead of mice, so that when in therapeutic use, the patient's immune system doesn't see the antibodies as being foreign.

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Monoclonal antibodies approaching a cancerous cell.