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Monoclonal Antibiotics


Progress With Monoclonal Antibodies


Scientists belonging to the Medical Reasearch council (MRC)have been working with monoclonal antibodies for the last 25 years. Below is a direct timeline of the research that has been done from the 1975 until present by the MRC.

ˇ 1975 - Mouse monoclonal antibodies isolated in Nobel Prize winning work by Dr César Milstein and Dr Georges Köhler, at the MRC Laboratory of Molecular Biology (LMB), Cambridge, UK.

ˇ 1980 - MRC know - how helps establish Celltech , the fore runner of the UK biotech industry. Celltech later sold its world-leading monoclonal antibodies manufacture contract to Lonza A.G.

ˇ 1986 - LMB scientists Dr Michael Neuberger and Dr Greg Winter pioneer techniques to "humanise" mouse monoclonal antibodies, making them better suited to human medical use.

ˇ 1989 Dr Neuberger, together with Dr Marianne Brüggemann of the BBSRC Babraham Institute, genetically engineers mice to produce fully human antibodies.

ˇ 1990 Dr Winter's team at LMB and the Cambridge MRC Centre for Protein Engineering (CPE) develops and patents test-tube production of human antibodies. M RC spin-out company, Cambridge Antibody Technology, founded to commercially exploit the new technology. MRC special grant helps Drs Geoff Hale and Herman Waldmann found the Cambridge Therapeutic Antibody Centre (TAC) to develop therapies using LMB mAbs.

ˇ 1995 TAC moves to Oxford to continue its MRC supported work.

ˇ 2000 Over 200 companies world-wide are marketing, or developing, research, diagnostic and therapeutic monoclonal antibodies applications, many based on innovative MRC technology.

From the timeline we can see what progress has been made on research for monoclonal antibodies. Also it allows us to only assume that the future technologies will ring more advances in this research.